Desmoplastic melanoma is a rare form of skin cancer that involves cancerous cells along with fibrous tissue and a high volume of collagen. People with desmoplastic melanoma often have patches of thickened skin that may resemble scars. These patches are cancerous growths, and they are most common on the head and neck. This form of melanoma primarily affects individuals over the age of 60 years and people with light skin tones. It is also more common in males than females. 

Desmoplastic melanoma may have a higher survival rate than other forms of melanoma.

A few of the most common symptoms of desmoplastic melanoma include:

• patches of skin that look like scars and have variable texture
• skin lesions that appear like thickened skin
• growths that are pink or the same tone as a person’s skin
• growths that are 6 millimeters (mm) or more in size

Certain desmoplastic melanoma growths may also bleed, itch, or sting.

Desmoplastic melanoma is closely related to sun exposure. The majority of desmoplastic melanomas appear on the head and neck. These two areas of the body are particularly susceptible to sun exposure. However, researchers do not fully understand the underlying causes of the condition.

People at the highest risk of this melanoma are generally white, male, and older than 60 years. A few risk factors for desmoplastic melanoma include:

• having sun-damaged skin
• having fair skin that is susceptible to sunburn
• having a prior melanoma diagnosis

Individuals who may be at risk of desmoplastic melanoma should consider attending regular skin cancer screenings. A healthcare professional can identify potential risk factors and provide guidance for each individual.

Information about the treatment options for desmoplastic melanoma is limited because the condition is rare. The most effective treatment for each case depends on the individual and the disease stage they are experiencing.

There are a variety of possible treatments for desmoplastic melanoma:

• Surgical treatment

• Radiotherapy

• Immunotherapy

• Targeted therapies

Desmoplastic melanoma is a type of skin cancer that is difficult for doctors to diagnose. A recent Chinese study found that only 27% of cases were accurately diagnosed after an initial examination. Healthcare professionals diagnose desmoplastic melanoma based on a number of factors. The shape of the cells in a particular sample may indicate the presence of the cancer. Certain protein markers like S-100 and SOX-10 may also be present. Doctors may use diagnostic tests such as dermoscopy (or dermatoscopy) and skin biopsy.

One 2019 study found that the overall 5-year survival rate for desmoplastic melanoma is 75%. However, there is a lack of data about this condition, making it difficult to define an accurate outlook and life expectancy. Early diagnosis and treatment may increase a person’s chance of recovery. Factors such as age and overall health may also contribute to someone’s outlook and life expectancy.

References: https://www.medicalnewstoday.com/articles/desmoplastic-melanoma